A spirit has taken up residence in the store, and although Melinda Gordon usually can sort out what's keeping a spirit from crossing over, this particular one is frustratingly uncommunicative. After a week of trying, the store owner is convinced that Melinda will never succeed.

Then self-acclaimed spiritual consultant Wendy King comes to town, guaranteeing success in moving spirits to the afterlife...for a fee. But Wendy's methodology involves trapping and forcing spirits into the light. And she pays no heed when Melinda tells her that what she is doing is wrong and dangerous.

After a young couple inherits the old Ray mansion and asks for help selling the antiques that fill the house, Melinda pushes aside her concerns about Wendy. But the old house holds a terrible secret and a spirit that Melinda cannot budge. The frightened owners turn to Wendy King, who forces the spirit to cross over, despite Melinda's pleadings. But Wendy's actions release an evil, unyielding spirit, one who promises to release a flood of disease and terror on the town, starting with the people closest to the Ghost Whisperer.