Karen Karbo's first novel, Trespassers Welcome Here, was a New York Times Notable Book of the Year, and a Village Voice Top Ten Book of the Year. Her other two adult novels, The Diamond Lane and Motherhood Made a Man Out of Me, were also named New York Times Notable Books.

Karbo's 2004 memoir, The Stuff of Life, about the last year she spent with her father before his death, was an NYT Notable Book, a People Magazine Critics' Choice, a Books for a Better Life Award finalist, and a winner of the Oregon Book Award for Creative Non-fiction. Her short stories, essays, articles and reviews have appeared in Elle, Vogue, Esquire, Outside, O, More, The New Republic, The New York Times, salon.com and other magazines.

She is a recipient of a National Endowment for the Arts Fellowship in Fiction, and a winner of the General Electric Younger Writer Award. Karbo is most well known for her best-selling Kick Ass Women series, the most recent of which is How Georgia Became O'Keeffe, published in 2011. How to Hepburn, published in 2007, was hailed by the Philadelphia Inquirer as "an exuberant celebration of a great original"; #1 ebook best-seller The Gospel According to Coco Chanel appeared in 2009.