The Lizard is wreaking havoc throughout the Everglades, as he seeks a cure for his dual identity as the reptilian villain and the human scientist Dr. Curt Connors--the result of an experiment gone horribly wrong. Spidey's attempts to halt the Lizard's rampage lead him to a web of intrigue and danger that may spell the destruction of a space-shuttle launch. The action heats up as Venom, the alien symbiote who wants Spider-Man dead, arrives, targets the Lizard for death, and won't let anyone stand in his way! Spider-Man must save the shuttle, halt the Lizard's rampage, and keep Venom from destroying the Lizard--and the helpless scientist trapped inside him--before it's too late!