The Neville sisters flourish in decadent, hedonistic London society in 1923: champagne, parties and the latest illegal substances. All except Charlotte, the middle of the three sisters who hides in a corner wishing she were back in Cambridge helping her professor father with his scientific experiments.

When Charlotte meets her father's new research assistant Karl, it is the beginning of a deadly obsession that divides her from her sisters, her father and even her dearest friend. What price are they willing to pay to stay together?