A plague of vampirism has crept across the country, reducing once-thriving cities to ghost towns. In Chicago, a few scattered survivors hide behind the fortified walls of office buildings and museums, raiding deserted stores for dwindling supplies of clothing and food. Meanwhile a hungry vampire population also struggles for survival as their prey grows scarce, forcing them to capture alive the last remaining humans as breeding stock for the blood farms that will ensure their future. Now a small band of humans makes a despearate last stand against their vampire masters, fighting back with the only weapon that can kill the dead...