The interactions between the plant, soil, and microbes are very complex in nature and may be antagonistic, mutualistic, or synergistic, depending upon the types of microorganisms and their association with the plant and soil. The multi-trophictactics are involved in these types of interactions to nourish the plants in various habitats and conditions. Understanding the mechanisms of these interactions is highly desired to utilize the knowledge in such an eco-friendly and sustainable way, which may not only resolve the upcoming food security issues but also make the environment green by reducing the chemical inputs. Plant, Soil and Microbes: Mechanisms and Molecular Interactions, along with the recently published Plant, Soil and Microbes: Implications in Crop Science, provide detailed accounts of the exquisite and delicate balance between the three critical components of agronomy. Specifically, these two titles focus on the basis of nutrient exchange between the microorganisms and the host plants, the mechanism of disease protection and the recent molecular details emerged from studying this multitropic interaction. Together they provide a solid foundation for the students, teachers, and researchers interested in soil microbiology, plant pathology, ecology and agronomy.