This book constitutes the thoroughly refereed papers from the BPM 2013 Joint Workshop on Process-Oriented Information Systems and Knowledge Representation in Health Care, KR4HC 2013/ProHealth 2013, held in Murcia, Spain, in June 2013. The 10 revised full papers presented together with 1 keynote paper were carefully reviewed and selected from 19 submissions. The papers are organized in topical sections on semantic interoperability in health care; modeling clinical guidelines; knowledge-based techniques for handling clinical data; and context aware services and guidance.