This text is a result of the 14th European Immunology Meeting (EFIS 2000), held in Poznan, Poland, 23-27 September 2000. EFIS 2000 gathered over 1400 immunologists from all over the world. It was a memorable meeting for a number of reasons: it was held in the last year of the century and the millennium, thus provoking conclusions of past achievements of immunology and projections for the future; it was held in Poland, a country that is a symbol of struggle for freedom for a large number of scientists originating from the "Eastern Bloc" countries; and EFIS celebrated its 25th anniversary at this occasion. This comprehensive volume contains 62 chapters grouped into 11 sections: T-cells, immune receptors, antigen presentation/dendritic cells, cytokines, immunodeficiencies, autoimmunity, allergy/inflammation, immunotherapy, vaccines, tumour immunology, and cancer immunotherapy.