Introduction (A. Aguirre, B. Foster, Z. Merali).- The paradigm of kinematics and dynamics must yield to causal structure (R. Spekkens).- Recognising Top-Down Causation (G. Ellis).- On the Foundational Assumptions of Modern Physics (B. Dribus).- The preferred system of reference reloaded (I. Perez).- Right about time? (S. Gryb, F. Mercati).- A critical look at the standard cosmological picture (D. Janzen).- Not on but of (O. Dreyer).- Patterns in the Fabric of Nature (S. Weinstein) Is quantum linear superposition an exact principle of nature? (A. Bassi, T. Singh, H. Ulbricht).- Quantum-informational Principles for Physics (G. D'Ariano).- The Universe is not a Computer (K. Wharton).- Against spacetime (G. Amelino-Camelia).- A chicken-and-egg problem: Which came first, the quantum state or spacetime? (T. Asselmeyer-Maluga).- Gravity can be neither classical nor quantized (S. Hossenfelder).- Weaving commutators: beyond Fock space (M. Arzano).- Reductionist Doubts (J. Barbour).- Rethinking the scientific enterprise: in defense of reductionism (I. Durham).- Is Life Fundamental? (S. Walker).