Scientists challenging dominant paradigms are either ignored or attacked by the scientific mainstream. This volume contains a selection of scientific papers presented at the two last GIRI meetings (International Research Group on Very Low Dose and High Dilution Effects). The majority of these papers present results performed with succussed high dilutions (homeopathic dilutions), even beyond the Avogrado number. All presented models are classified, and their interpretation is possible either in the mechanistic paradigm or in an information paradigm. This new field of research introduces new scientific concepts which are supported by experimental results. Furthermore, this nascent science is totally concerned with living organisms and, as such, it becomes necessary to define `information' brought by non-molecular high dilutions. This book presents brain-storming work of this research group and is one of the starting points of a scientific evolution.