In The Blind Spot, astrophysicist Adam Frank, theoretical physicist Marcelo Gleiser, and philosopher Evan Thompson call for a revolutionary scientific worldview, where science includes--rather than ignores or tries not to see--humanity's lived experience as an inescapable part of our search for objective truth. They urge practitioners to reframe how science works for the sake of our future in the face of the planetary climate crisis and increasing science denialism. When we try to understand reality only through external physical things imagined from this outside position, we lose sight of the necessity of experience. This is the Blind Spot, which the authors show lies behind our scientific conundrums about time and the origin of the universe, quantum physics, life, AI and the mind, consciousness, and Earth as a planetary system. The authors propose an alternative vision: scientific knowledge is a self-correcting narrative made from the world and our experience of it evolving together. The Blind Spot goes where no science book goes, urging us to create a new scientific culture that views ourselves both as an expression of nature and as a source of nature's self-understanding, so that humanity can flourish in the new millennium.