Structure: Nuclear Magnetic Resonance Studies of ThrombinFibrinopeptide and ThrombinHirudin Complexes (F. Ni et al.). ESR and Flourescence Studies of Thrombin Active Site Conformation (L.J. Berliner). Biochemistry: Synthetic Substrates and Inhibitors of Thrombin (J.C. Powers, C.M. Kam). Regulation of Thrombin by Antithrombin and Heparin Cofactor II (S.T. Olson, I. Bjoerk). Hirudin Interactions with Thrombin (S.R. Stone, J.M. Maraganore). Physiology: Functional Domains in Thrombin Outside the Catalytic Site (R. BarShavit et al.). Post Clotting Cellular Effects of Thrombin Mediated by Interaction with HighAffinity Thrombin Receptors (D.H. Carney). Regulation of ThrombinInduced Endothelial Barrier Dysfunction and Prostaglandin Synthesis (J.G.N. Garcia et al.). 3 additional articles. Index.