When Sherlock Holmes gives up the adventurous life of a consulting detective and retires to the Sussex countryside to raise bees, little does he or his old friend Dr. John Watson realize that their greatest adventure lies ahead -- an adventure spanning centuries and extending across the solar system.

The future of civilization is at stake as Sherlock Holmes finds imself moving inexorably toward the final and most terrible confrontation with his ancient enemy, the time-jumping Napoleon of Crime, Professor Moriarty.