Learning and life are filled with uncertainty. Although the experience of uncertainty can cause emotional discomfort or cognitive rigidity, uncertainty serves as a catalyst and condition for change. In this way, uncertainty represents a core facet in the interrelationship among creativity, learning, and development. Considerations for both the benefits and potential costs of uncertainty will be addressed in this volume with an aim of understanding how uncertainty can be better understood in light of creativity, learning, and development. Taken together this volume stands to contribute to our collective understanding of the role that uncertainty plays in learning and life and highlights how conceptualizing and studying uncertainty in new ways can promote positive and lasting change.