Urinary Incontinence: Integrating Science and Clinical Practice provides a succinct elaboration of the current understanding of the system function of lower urinary tract physiology from world-leading contributors and clinical relevance. Key influences on mechanisms and therapies within urinary incontinence are presented for proper understanding of the scientific basis of incontinence and its clinical treatment. The first part of the book is dedicated to System Physiology: Function and Adaptation. In this section an anatomical sequence is followed for presenting the chapters, moving from the lower urinary tract organs upwards through the spinal centers to the brain, thus revealing what is known and unknown. The second is dedicated to Incontinence: Mechanism and Therapy. In this clinical application section, the chapters will be derived from the clinical classification of incontinence, incorporating some of the major unanswered questions, such as; what urodynamics can tell us about the passive physical and contractile properties of the bladder; how neuromodulation works; the sensations arising from the LUT; how the physical properties of the outflow tract are obtained from urethral pressure profiles; how PET and fMRI images are interpreted and what principles of drug design and outcome measures are validated as repeatable.