After the horror the Cobra unleashed upon Metro City, Paul Sanderson has recuperated, regained his strength and focus, and the city has been rebuilt while its citizens have slowly started to regroup and move forward. Into this relative calm marches Ma Tzi, the Hong Kong drug lord, who senses a weakness in resident crime lord Robert Latham's hold on the city, and intends to exploit that in any way necessary. And at any cost. In the midst of their vicious gang war, a new terror envelopes the city -- a virulent plague wipes out thousands, a plague that The Wraith soon discovers to be man-made. With no end in sight, and his assistant Max Horton missing, can The Wraith stop Latham and Tzi from causing further carnage, save countless lives and find those responsible for the heinous slaughter of innumerable innocents?