A Las Vegas showgirl, a diner waitress, and a heartbroken alcoholic—three sisters—are called into an obligatory reunion in California's Central Valley in the late 1990s as a prelude to their mother's impending death.

Inside Diego's Diner on Highway 99, Lorraine, the eldest of the sisters, attempts to convert the truckers and regional farmers to her religious beliefs while managing the counters and booths. Becky, the youngest, lurches into this scene after a night's drunken romp. Meanwhile, middle sister Julie is en route on a bus from Las Vegas, where she's just ended a long career as a Riviera showgirl. Overshadowing the longstanding tensions between the three women is the unexplained disappearance of the sisters' long-absent father from their lives.

Julie is reluctant to return to River's End, but she makes a valiant attempt to jump-start her life again once she gets there, even as she confronts the loss of the beauty she's long used to mask her insecurities and failed relationships. Meanwhile, Becky struggles to stay sober and out of jail—and Lorraine throws herself into cheating her sisters out of their inheritance.