This Festschrift honors Professor Dr.-Ing. habil. Michael Kaliske on his 65th birthday, celebrating his significant contributions to computational mechanics. Renowned for his work in multiphysical constitutive modeling, fracture and damage mechanics, and Arbitrary Lagrangian–Eulerian (ALE) formulations within the Finite Element Method, Professor Kaliske has established an extensive international network of collaborators. This volume brings together contributions from esteemed colleagues, former PhD students, and friends worldwide, reflecting on his impact and presenting insights into the latest developments in computational mechanics. Computational mechanics is currently part of many engineering tasks and disciplines. The book contains a state-of-the-art with respect to machine learning tools in biomechanics, digitization in engineering, damage mechanics, brittle and ductile fracture modeling, multi-physical and non-linear constitutive modeling with various applications, scaled boundary finite-element frameworks, material point and finite-element methods, data-driven mechanics, polymorphic uncertainty quantification, validation experiments in civil engineering, tire mechanics, space-time finite elements as well as topology optimization approaches.