This proceedings volume features top contributions in modern statistical methods from Statistics 2021 Canada, the 6th Annual Canadian Conference in Applied Statistics, held virtually on July 15-18, 2021. Papers are contributed from established and emerging scholars, covering cutting-edge and contemporary innovative techniques in statistics and data science. Major areas of contribution include Bayesian statistics; computational statistics; data science; semi-parametric regression; and stochastic methods in biology, crop science, ecology and engineering. It will be a valuable edited collection for graduate students, researchers, and practitioners in a wide array of applied statistical and data science methods.