First published in 1925, 'Arrowsmith' is a novel by American author Sinclair Lewis. It is arguably the earliest major novel to deal with the culture of science. It was written in the period after the reforms of medical education flowing from the Flexner Report on Medical Education in the United States and Canada: A Report to the Carnegie Foundation for the Advancement of Teaching, 1910, which had called on medical schools in the United States to adhere to mainstream science in their teaching and research.