This book constitutes the refereed proceedings of the Third International Conference on Artificial Intelligence in HCI, AI-HCI 2022, which was held as part of HCI International 2022 and took place virtually during June 26 – July 1, 2022.

A total of 1271 papers and 275 posters included in the 39 HCII 2022 proceedings volumes. AI-HCI 2022 includes a total of 39 papers; they are grouped thematically as follows: Human-Centered AI; Explainable and Trustworthy AI; UX Design and Evaluation of AI-Enabled Systems; AI Applications in HCI.