The book will be focused on the new advances in the design, preparation and application of different hybrid catalysts such as artificial metalloenzymes. The different chapters will cover different important aspect such as computational tools, preparation of artificial enzymes by using noncanonical aminoacids, nanobiocatalysts, protein-cages, enzyme-polymer conjugates, enzyme-metal nanoparticles hybrids as enzyme mimics, or hybrid systems with applications as antimicrobial agents.