This book highlights research and survey articles dedicated to big data techniques for cyber-physical system (CPS), which addresses the close interactions and feedback controls between cyber components and physical components. The book first discusses some fundamental big data problems and solutions in large scale distributed CPSs. The book then addresses the design and control challenges in multiple CPS domains such as vehicular system, smart city, smart building, and digital microfluidic biochips. This book also presents the recent advances and trends in the maritime simulation system and the flood defence system.