This book constitutes the refereed proceedings of the First International Conference on Constructive Approaches for Security Analysis and Design of Embedded Systems, CASCADE 2025, held in Saint-Etienne, France, during April 2–4, 2025.

The 24 full papers included in this book were carefully reviewed and selected from 51 submissions. They are organized in topical sections as follows: Attacks on Symmetric Cryptography; Side-Channel Attacks; Physical Security; RISC-V**;** Machine Learning; Attacks on Post-Quantum Cryptography; Securing Post-Quantum Cryptography; Homomorphic Encryption and White-Box Cryptography; Attacks on Symmetric Cryptography; Side-Channel Attacks; Physical Security; RISC-V; and Machine Learning.