When a surge of drug-resistant staph infections occurs in three hospitals run by Angels Healthcare, the fatalities also cause stock prices to tumble.

New York City medical examiners Laurie Montgomery and Jack Stapleton are naturally intrigued by the up-tick in staph-related post-procedure deaths. Aside from their own professional curiosity, there's a personal stake as well: Laurie and Jack are newly married, and Jack is facing surgery to repair a torn ligament at Angels Orthopaedic Hospital. Despite Jack's protests, Laurie can't help investigating - opening a Pandora's box of corporate intrigue that threatens not just her livelihood, but her life with Jack as well.