This volume presents recent biotechnological advances in the application of extremophiles in sustainable agricultural production, plant health and soil remediation. It highlights the physiology and biochemistry of extremophiles to ensure their survival and adaptation under stressful agricultural conditions, as well as their ecological diversity and taxonomical attributes that allow them to be useful in improving abiotic and biotic tolerance among crops. The chapters cover genomic, metagenomic and metabolomic approaches for improving crop production, biocontrol, nutrient solubilization and soil health to ensure food and nutrition security in a sustainable manner in difficult growing environments. The book will be useful for students and researchers studying soil and plant management, sustainable agriculture, microbiology and biochemistry.