This book constitutes the refereed proceedings of the 6th Latin American Conference on Geographical, Information Systems, GIS-LATAM 2025, held in Mexico City, Mexico, during September 8–12, 2025.

The 12 full papers were thoroughly reviewed and selected from 35 submissions. These papers focus on the following topics: Sustainable Energy and Resource Management, Environmental Monitoring and Management, Public Health and Social Issues, Education and Technology in GIS, and Climatic Patterns and Natural Disasters.