This book highlights the advancement of graphene-based non-invasive sensors for health monitoring. Graphene has been considered the strongest and thinnest known material to date. Unlike most semiconductor systems, its two-dimensional (2D) electronic state can be accessed directly by tunneling or other local probes. With their mechanical, thermal, and electrical properties, graphene-based materials have shown effectiveness in sensing various biophysical and biochemical signals such as body temperature, heart rate, respiration rate, blood pressure, blood glucose levels and electrocardiograms, electromyograms, and electroencephalograms.