The volume includes papers presented at the International KES Conference on Human Centred Intelligent Systems 2025 (KES HCIS 2025), held in Solin, Croatia on June 25–27, 2025. This book highlights new trends and challenges in intelligent systems, which play an important part in the digital transformation of many areas of science and practice. The selected articles are offering a deeper understanding of the human-centred perspective on artificial intelligence, assessment collaborative creation, ethics, value-oriented digital models, transparency, and intelligent digital architectures and engineering. These are supporting digital services and intelligent systems, the transformation of structures in digital businesses and intelligent systems based on human practices, as well as the study of interaction and the co-adaptation of humans and systems.