The coronavirus disease (COVID-19) has had a devastating impact on global aviation as nearly all air travel came to a halt in late March and April 2020. In Central Asia, virtually all domestic and international air travel were suspended in an attempt to contain the spread of COVID-19. This crisis provides an opportunity to reset the aviation industry in Central Asia Regional Cooperation (CAREC) countries through reforms, new strategies, and restructurings. This study of the pandemic’s impact on CAREC and the aviation industry looks at the gravity of the situation, explores opportunities, and offers some recommendations for dealing with the crisis and facilitating a fast recovery.