This two-volume set constitutes the refereed proceedings of the Second International Conference, ISDS 2024, held in Nha Trang, Vietnam, during November 9–10, 2024.

The 38 full papers and 10 short papers were carefully reviewed and selected from 129 submissions. They were categorized under the topical sections as follows: AI in E-Commerce, Agriculture, and Aquaculture; AI in Health Care Analytics; Big Data, IoT, and Cloud Computing; and Natural Language Processing.