This volume constitutes selected papers presented during the Second International Conference on Intelligent Systems and Pattern Recognition, ISPR 2022, held in Hammamet, Tunisia, in March 2022. Due to the COVID-19 pandemic the conference was held online.

The 22 full papers and 10 short papers presented were thoroughly reviewed and selected from the 91 submissions. The papers are organized in the following topical sections: computer vision; data mining; pattern recognition; machine and deep learning.