This book provides a comprehensive overview of Japanese Encephalitis (JE), its pathobiology, and associated challenges for treatment and prevention. It focuses on various aspects of Japanese Encephalitis, including global epidemiology, genome organization and genotypes, virus-host interactions, immunopathogenesis, transmission dynamics, antibody-dependent enhancement, clinical characteristics, laboratory diagnosis, treatment, prevention, and control strategies. It provides a brief account of the Japanese encephalitis vaccine, their immunogenicity, protective ability, and impact of JE’s vaccine in reducing the burden of the disease. It also helps in understanding the molecular and cellular factors involved in the JE virus neuro-invasion and inflammatory processes. The book uniquely presents cutting-edge information and provides an edited information source for clinicians, virologists, pathologists, and immunologists.