This volume presents state-of-the-art tools and techniques for automatically detecting, diagnosing, and predicting the effects of adverse events in an engineered system. It emphasizes the importance of these techniques in managing the intricate interactions within and between engineering systems to maintain a high degree of reliability. Reflecting the interdisciplinary nature of the field, the book explains how the fundamental algorithms and methods of both physics-based and data-driven approaches effectively address systems health management in application areas such as data centers, aircraft, and software systems.