Main Street is a satirical novel written by Sinclair Lewis, and published in 1920.

Satirizing small town life, Main Street is perhaps Sinclair Lewis's most famous book, and led in part to his eventual 1930 Nobel Prize for Literature. It relates the life and struggles of Carol Milford Kennicott in the small town of Gopher Prairie, Minnesota, as she comes into conflict with the small-town mentality of its residents. Highly acclaimed upon publication, Main Street remains a recognized American classic.

In 1998, the Modern Library ranked Main Street #68 on its list of the 100 best English-language novels of the 20th century.