This book gathers the latest advances, innovations, and applications in the field of multibody and mechatronic systems. Topics addressed include the analysis and synthesis of mechanisms; modelling and simulation of multibody systems; railway and vehicle dynamics; mechatronic systems and assistive technology and rehabilitation; robot design and optimization; and mechatronic design. It gathers the proceedings of the 8th International Symposium on Multibody Systems and Mechatronics (MuSMe), held in Guadalajara, Mexico, on October 21-24, 2025, within the framework of IFToMM Technical Committees for Multibody Dynamics and for Robotics and Mechatronics.