This book constitutes the post-conference proceedings of the 12th Multidisciplinary International Social Networks Conference, MISNC 2025, held in Oviedo, Spain, during September 3–5, 2025.

The 42 full papers included in this book were carefully reviewed and selected from 89 submissions. They are organized in topical sections as follows: Multidisciplinary Social Networks Research; Generative AI and the Future of Social Content: Opportunities and Challenges; Advanced Social Computing through AI-centric Multidisciplinary Fusion; Network, Economic and Business Studies.