This book constitutes the refereed proceedings of the 4th Southwest Data Science Conference on New Frontiers in Data Science, SDSC 2025, held in Waco, TX, USA, during March 21–22, 2025.

The 11 full papers and included in this book were carefully reviewed and selected from 64 submissions. They were organized in topical sections as follows: Ethical AI-Driven Data Science; New Data-Science Infrastructure & Platforms; Attention-Enhanced Deep Learning; Biomedical & Educational Data Science; and AI-Driven Supply Chain & Operations Management.