This open access book offers a comprehensive overview of nuclear technologies and the nuclear supply chain. It explores nuclear energy as a critical resource through economic, geopolitical, and social lenses, assessing its potential role in combating climate change. The book also addresses key challenges, including nuclear waste management, decommissioning, and back-end operations. By examining both historical hurdles and future policy and industry obstacles, it provides valuable insights for policymakers, researchers, and industry professionals navigating the evolving landscape of nuclear energy.