This book constitutes the proceedings of the 19th International Conference on Reachability Problems, RP 2025, which took place in Madrid, Spain, during October 1-3, 2025.

The 12 full papers included in these proceedings were carefully reviewed and selected from 35 submissions. The book also contains three invited talks in full paper length. The papers cover topics in reachability problems that appear, among others, in algebraic structures, automata theory and formal languages, computational game theory, concurrency and distributed computation, decision procedures in computational models, hybrid dynamical systems, logic and model checking, and verification of finite- and infinite-state systems.