This book comprises select proceedings of the 7th International Conference on Data Science and Engineering (ICDSE 2021). The contents of this book focus on responsible data science. This book tries to integrate research across diverse topics related to data science, such as fairness, trust, ethics, confidentiality, transparency, and accuracy. The chapters in this book represent research from different perspectives that offer novel theoretical implications that span multiple disciplines. The book will serve as a reference resource for researchers and practitioners in academia and industry.