It's 1921 and Cranston Walker is hunting masked arsonist. The Walker Corporation's newest business partner is Saint Moon Foods. No sooner has Saint Moon opened its first factory in Silkhaven, but a masked woman claims that there is poison in their beer and attempts to dynamite the factory. Cranston has long suspected that Saint Moon is planning something nefarious. Their president, Edward Blake, is a very public eugenicist and rumors of a secret project have been floating around for years. Cranston would like a word with this masked woman, but he has to convince her that they're on the same side.

Meanwhile, Vivienne Walker is befriending Edward's fresh-from-university children, Gabrielle and Michael, which sees Vivienne getting dragged into a romantic intrigue. Michael is in love with a journalist, which is just about the worst kind of woman that a rich, young man could fall in love with. However, earning the twins' collective trust could be Vivienne's ticket into discovering the truth behind Saint Moon's secret project.

'Rise of the Virago' is a sensational ride through the city of Silkhaven as vigilantes, private security, licensed sex workers, politically partisan police officers, and an honest-to-god high-seas pirate collide in a race for the truth.