This book constitutes the conference proceedings of the 22nd International Conference on Smart Business Technologies, ICSBT 2025 held in Bilbao, Spain, during June 11–12, 2025.

The 19 full papers included in this book were carefully reviewed and selected from 39 submissions.They focus on the conference theme “Artificial Intelligence and The Future of GenAI in Business”, highlighting the transformative potential of Generative AI and its applications in the business world**.**