This volume contains 74 papers presented at SCI 2016: First International Conference on Smart Computing and Informatics. The conference was held during 3-4 March 2017, Visakhapatnam, India and organized communally by ANITS, Visakhapatnam and supported technically by CSI Division V – Education and Research and PRF, Vizag. This volume contains papers mainly focused on applications of advanced intelligent techniques to video processing, medical imaging, machine learning, sensor technologies, and network security.