Smart Systems for Disease Prediction: Advancements, Applications and Challenges is a comprehensive book that explores the use of intelligent technologies to predict diseases accurately and efficiently. It covers a wide range of topics, including image and signal processing, behavioural analysis, and the integration of multimodal data in healthcare. The book examines the application of artificial intelligence, machine learning, and data analytics in creating predictive models for diseases. It also addresses the challenges, ethical considerations, and future directions in the field. This work emphasises the significant impact of intelligent systems on enabling early diagnosis, personalised medicine, and improving patient outcomes.