This book constitutes the first part of refereed proceedings of the 5th Computational Methods in Systems and Software 2021 (CoMeSySo 2021). The CoMeSySo 2021 Conference is breaking the barriers, being held online. CoMeSySo 2021 intends to provide an international forum for the discussion of the latest high-quality research results.

The software engineering, computer science, and artificial intelligence are crucial topics for the research within an intelligent systems problem domain.