This volume is dedicated to the centennial anniversary of Minkowski's discovery of spacetime. It contains selected papers by physicists and philosophers on the Nature and Ontology of Spacetime. The first six papers, comprising Part I of the book, provide examples of the impact of Minkowski's spacetime representation of special relativity on the twentieth century physics. Part II also contains six papers which deal with implications of Minkowski's ideas for the philosophy of space and time. The last part is represented by two papers which explore the influence of Minkowski's ideas beyond the philosophy of space and time.