For decades, tired travellers have stopped at rest areas on America's epic highways to rest, refuel and get a bite to eat, but little do they know that one man's rest stop is another's hunting ground. For years the defenceless, the weary and the stranded have been disappearing along the highways and byways, vanishing without a trace.

When FBI special agent Maggie O'Dell and her partner, Tully, discover the remains of a young woman in a highway ditch, the one clue left behind is a map that will send Maggie and Tully on a frantic hunt crisscrossing the country to stop a madman before he kills again.

As the body count rises and Maggie races against the clock to unmask the monster who's terrorising the nation's highways, she turns for help to a former foe who seems to have an uncanny knack for guessing what the killer's next move will be. But as she gets closer to finding the killer, it becomes eerily clear that Maggie is the ultimate target.