This book constitutes the refereed proceedings of the 16th IFIP WG 5.5/SOCOLNET Advanced Doctoral Conference on Computing, Electrical and Industrial Systems on Technological Innovation for AI-Powered Cyber-Physical Systems, DoCEIS 2025, held in Lisbon, Portugal, during July 2–4, 2025.

The 29 full papers presented were carefully reviewed and selected from 60 submissions. They were focused on topical sections as follows: AI in Business Applications; AI in Industry 4.0; Smart Systems in Sustainable Development; AI-Powered Healthcare; AI in Systems, Decision & Control; Intelligent Sensing & Communication Systems; Smart Power Systems; Electronic Systems.