Only the bravest felines dare to enter the Isle of Dogs.

On the trail of a missing inventor called Quincy, cat reporter Julius Kyle follows a dangerous trail through mountains and savannahs to Alcander, a city built and run by canines. With the help of his streetwise Siamese partner Moira, he uncovers a conspiracy to overthrow the lapdog government and unleash the underdogs who make the city tick.

Back in Julius's hometown, a mayoral election heats up. The candidates are all willing to do anything to win, from caging the incumbent mayor, to setting his mother adrift at sea with no one for company but a Tonkinese toady. While the candidates face an incursion of vermin, Julius must find Quincy before he builds a weapon capable of ruining the dogs' world forever.